Data-driven reverse engineering of signaling pathways using ensembles of dynamic models
نویسندگان
چکیده
منابع مشابه
Data-driven reverse engineering of signaling pathways using ensembles of dynamic models
Despite significant efforts and remarkable progress, the inference of signaling networks from experimental data remains very challenging. The problem is particularly difficult when the objective is to obtain a dynamic model capable of predicting the effect of novel perturbations not considered during model training. The problem is ill-posed due to the nonlinear nature of these systems, the fact...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2017
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1005379